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Michael G. Chez, M.D., Cathleen P. Buchanan, Ph.D., Jamie L. Komen, M.A., Marina Becker, R.N. Journal of Child Neurology (accepted for publication 2003). Pediatric Neurology, Lake Forest Hospital, Illinois 60045, USA. firstname.lastname@example.org (PubMed – Abstract)
Objective: L-Carnosine is an amino acid dipeptide that may enhance frontal lobe function. We therefore sought to investigate whether L-Carnosine supplementation for children with Autistic Spectrum Disorders (ASD) results in observable, objective changes in language and/or behavior in contrast to placebo.
Design/Methods: Thirty-one children (21 M, mean age= 7.45; range = 3.2-12.5 yrs) meeting inclusion criteria were enrolled in an 8 week blinded trial of either 400 mg BID powdered L-Carnosine or placebo. Children were assessed at a pediatric neurology clinic with the Childhood Autism Rating Scale (CARS), the Gilliam Autism Rating Scale (GARS), the Expressive and Receptive One-Word Picture Vocabulary tests (E/ROWPVT), and biweekly parental Clinical Global Impression of Change (CGI), at baseline and 8 week endpoint. Dr Michael G. Chez is specialist and associate professor in Child Neurology Results: Children who were on placebo (n=17) did not show statistically significant changes on any of the outcome measures. After 8 weeks on L-Carnosine, children (n=14) showed statistically significant improvements on the GARS total score, GARS Behavior, Socialization, and Communication subscales, and the ROWPVT (all p’s<.05). E/ROWPVT and CARS showed trends in improvements, which were supported by parental CGI.
Conclusions: Oral supplementation with 400mg L-Carnosine resulted in demonstrable improvements in autistic behaviors as well as increases in language comprehension that reached statistical significance. Although the mechanism of action of the amino acid is not well understood, it is believed that it acts to modulate neurotransmission and affect metal ion transfer of zinc and copper in the entorhinal cortex. This may enhance neurological function or act in a neuroprotective fashion.
If you read about me you will see I am a Chiropractor and Massage therapist, so I have seen a lot of people in pain and none of it is good. From a therapists point of view pain makes my job difficult, everything is self-protective, reactive and so much of your time is wasted placating the pain reaction that is happening in the tissues.
Recently I got my first opportunity to test out the LifeWave pain patches-IceWave. I had heard good reports that 80% of people will experience 50% or greater pain relief in under 5 minutes. I had heard of a few cases from colleagues where long standing conditions had been almost instantly relieved and so I had to check it out for myself.
Fiona is a single Mum with three active kids and a knee crushed from a horse falling on it over 20 years ago. The injury has caused her a lot of problems over the years, but recently it flared up badly and when I saw her she was in excruciating pain, she did not want to move it at all which made Physio virtually impossible, she had knife like pain traveling through the whole leg and her inner thigh had turned into a soft pulpy jelly- a reflex inhibition of the Vastus Medialis Oblique muscle that often occurs with knee problems and further complicates rehab.
There is not really much you can do while someone is in that much pain apart from ice/heat/ultrasound, acupuncture would be beneficial but I don’t practice it. Forget any physical therapy-even the lightest pressure was intensely painful and any muscle activation or joint movement was impossible. Not nice.
So, I pulled out a set of patches, put the brown patch over the main pain and the white one just above it. Immediately Fiona experienced warmth and smelt wintergreen. The sharp pain vanished and within a few minutes she did 10 good quad pumps. She kept saying, “What the #### is in those patches! This is unbelievable”. Fiona has had a colorful past…
The interesting thing is there is no wintergreen in the patches and no heat producing chemicals… this reaction is purely energetic. The patches emit a particular energetic frequency that takes away pain.
I then felt to move the white patch to her sternum and she experienced a tremendous energetic release. I could see the goosebumps all over her arms and legs. It was stinking hot in Australia this day, so it wasn’t the cold. She said she was feeling calmness and a sense of wellbeing and the pent up stress that has accompanied this and other issues seemed to leave her body.
I have never seen such a powerful change or received such heartfelt thanks from someone whose life I have just helped. And it was all so easy, and all so quick. What a great adjunct to a busy practice. My new protocol for acute pain will be to patch up patients first for three days, then get them in to start therapy. It will make my job way easier. Will keep you posted in this.
If you want to find out more about LifeWave patches, you can go to their web site click on products and then IceWave for pain relief. They have a trial pack for under $20. Please let me know what your story is. They come with a money back guarantee as well. If you need a number to order, use 666757.
INTERCURE RANKED NUMBER 136 FASTEST GROWING TECHNOLOGY COMPANY ON THE DELOITTE TECHNOLOGY FAST 500 EMEA 2008.
Attributes 1,227 Percent Revenue Growth to Successful Expansion into Retail Stores
New York, N.Y. – January 12, 2009 InterCure Ltd., a medical device company publicly traded on the Tel-Aviv Stock Exchange (TASE: INCR), today announced that it ranked Number 136 on the Deloitte Technology Fast 500 EMEA 2008, a ranking of the 500 fastest growing technology companies in EMEA. Rankings are based on percentage revenue growth over five years. InterCure grew 1,227 percent during this period.
“Being named as one of the 500 fastest growing technology companies in Europe, Middle East and Africa is a significant recognition for InterCure and indicative of our continued growth and success over the past five years,” said Erez Gavish, president and CEO of InterCure. “Our launch into the retail market allowed us to expand our business and extend our reach, placing RESPeRATE onto the shelves of the neighborhood pharmacies and into the homes of thousands more hypertension sufferers worldwide.”
“Making the Deloitte Technology Fast 500 is commendable in today’s highly competitive technology industry,” said Karel Bakkes, partner in charge of Deloitte’s Technology Fast 500 EMEA program. “We congratulate InterCure on being one of the 500 fastest growing technology companies in the region.”
InterCure previously ranked 170 on 2007 Deloitte Technology Fast 500.
Overall, companies that ranked on the Technology Fast 500 EMEA 2008 program had an average growth rate of 1,297 percent.
About InterCure Ltd. and RESPeRATE
InterCure Ltd. (Tel-Aviv Stock Exchange: INCR) is disrupting the $42 billion hypertension industry with the world’s first FDA-cleared, OTC blood pressure treatment device, RESPeRATE® (www.resperate.com). In a market where seven out of 10 hypertensives are NOT controlled despite the availability of more than 100 blood pressure medications, RESPeRATE provides an effective adjunctive non-drug therapy with no side effects.
RESPeRATE has gained widespread support of hypertension specialists and has secured regulatory clearance in most key international markets. Ten separate clinical studies have proven the device’s efficacy and safety, and RESPeRATE is now featured in more than 20 popular and professional text books.
With more than 100,000 units sold, thousands of supportive clinicians worldwide and one of the world’s most popular hypertension websites, InterCure is now introducing RESPeRATE into retail pharmacies to increase access to hypertension sufferers.
InterCure has an exciting product pipeline based on its broadly-patented “Device-Guided Breathing” technology platform. This technology enables a systematic reduction in sympathetic outflow of the autonomic nervous system, one of the key underlying causes of cardiovascular disease, insomnia and several other medical conditions.
When I was working in a very stressful role in Corporate Health, my body finally said very loudly “Enough of this folly!”. My blood pressure went through the roof and I ended up having a complete nervous collapse, ending up with chronic fatigue requiring bed rest for 8 months. Fortunately for me, I had someone come to the office and share Resperate with me. I thought it was a great device, well backed by research and introduced its use into our Health Expos. My plan then, and I still see this happening in due time, was to create relaxation rooms for employees and Resperate, among other things, would be available for employees to use when they needed to chill out. When everthing went pear shaped, I had the Resperate to help calm me down (I also developed anxiety and panic attacks). It was such a blessing. I really believe in this product, particularly where stress is a factor in your health issues. Many people, like me, have high BP that does not repond particularly well to medication, and it is very important for our health that BP is as normal as possible.
Using the Resperate is very relaxing. It uses musical notes, initially that change in time with your breathing and then gradually the notes go for longer, and your breathing slows. They say that if breath rate goes down to under 7/minute for 10 minutes or so the autonomic nervous system relaxes. Its like the Resperate pulls the stress out of your body. But there’s more to it than that. The biofeedback device that is strapped around your chest monitors whether you are listening and timing your breathing to the notes. Often people’s mind can wander, even without them knowing it and their breath rate increases. They find themselves thinking about how horrible and mean the neighbour was about the dog barking, concern over the daughters new boyfriend blah blah blah…that stinking thinking has major magnetism…When this happens the Resperate picks up that you are not listening and concentrating and has all sorts of strategies built in to “wake you up” and bring you back on track. While the Resperate has been proven to lower blood pressure, I belive that is just one of the benefits of learning how to spend 15 minutes a day doing nothing but breathing. It is a way to meditate and chill out for the everyday man.